"It is a capital mistake to theorize before you have all the evidence. It biases the judgment." ~ A Study in Scarlet

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"What the deuce is it to me?" he interrupted impatiently; "you say that we go round the sun. If we went round the moon it would not make a pennyworth of difference to me or to my work." ~ A Study in Scarlet

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"They say that genius is an infinite capacity for taking pains," he remarked with a smile. "It's a very bad definition, but it does apply to detective work." ~ A Study in Scarlet

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"In solving a problem of this sort, the grand thing is to be able to reason backwards. That is a very useful accomplishment, and a very easy one, but people do not practise it much. In the every-day affairs of life it is more useful to reason forwards, and so the other comes to be neglected. There are fifty who can reason synthetically for one who can reason analytically." ~ A Study in Scarlet

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"One's ideas must be as broad as Nature if they are to interpret Nature," he answered. ~ A Study in Scarlet

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I had neither kith nor kin in England, and was therefore as free as air -- or as free as an income of eleven shillings and sixpence a day will permit a man to be. Under such circumstances, I naturally gravitated to London, that great cesspool into which all the loungers and idlers of the Empire are irresistibly drained. ~ A Study in Scarlet

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"There's more work to be got out of one of those little beggars than out of a dozen of the force," Holmes remarked. "The mere sight of an official-looking person seals men's lips. These youngsters, however, go everywhere and hear everything. They are as sharp as needles, too; all they want is organization." ~ A Study in Scarlet

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"Yes, I have a turn both for observation and for deduction. The theories which I have expressed there, and which appear to you to be so chimerical are really extremely practical -- so practical that I depend upon them for my bread and cheese." ~ A Study in Scarlet

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